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Our ability to get pregnant is something many women take for granted. But as those who have had difficulty conceiving know all too well, deciding on how to improve your chances of becoming a mother is anything but simple. One option your doctor may present to you is fertility drugs. But before he does, it's best to be informed about the advantages and disadvantages of such treatment.
One commonly prescribed fertility drug is Clomid – but what are the potential side effects of this medication? Dr. Frederick R. Jelovsek gives you detailed advice on what taking this drug might mean for you. If Clomid doesn't work for you your doctor may prescribe the drug Tamoxifen / Nolvadex. Find an overview of different types of fertility drugs, such as recombinant follicle stimulating hormone (rFSH), including the common symptoms and multiple pregnancy risks with which they are associated, at Fertility Drugs.
Other fertility drugs that your doctor may prescribe to boost your fertility include:
And no matter what type of medicine you choose to take, you will want to learn about the costs involved with taking fertility drugs. Find out about the costs of common fertility drugs, as well as assisted reproductive technologies like in vitro fertilization at Fertility Drug Costs. Here you'll also find advice on financial planning and whether your health insurance plan will cover your fertility treatment costs.
Fertility drugs are the first step in fertility treatment. Infertility affects 7.1% of married couples in the United States, a figure that represents 2.8 million married couples.
Several factors can lead to infertility, including poor egg production and quality and irregular or lack of ovulation due to a hormonal balance may also result in infertility.
Polycystic Ovarian Syndrome (PCOS) can also result in infertility; PCOS is caused by a hormonal imbalance that leads to the inability to release eggs. PCOS may also result in painful cysts.
The fact that women today are generally trying to conceive later in life is also a factor that can affect the quality of her eggs and lead to her to turn to fertility drug treatment.
Poor sperm count and quality is another reason why couples have trouble conceiving on their own.
Common Fertility Drugs
Fertility drugs promote ovulation by stimulating hormones in the brain which control egg production.
Clomiphene is one common fertility drug. This drug, more commonly known as Clomid, is taken in a daily pill form. It is particularly helpful for women who have PCOS, and also helps with hormonal imbalances linked to low sperm count, quality and mobility.
Gonadotropins (also known as Pergonal) is used in cases when clomiphene isn't effective. It is administered via an injection on the third day of a woman's menstrual cycle, a dose that is continued for a period of seven to twelve days. Gonadoptropins works best for women who have PCOS or who have unexplained fertility problems. It can be used in conjunction with In Vitro Fertilization (IVF) to stimulate egg production.
On the other hand, bromocriptine is prescribed when ovulation problems are caused by pituitary adenoma, a benign tumor. Bromocriptine, which is also known as Parlodel, can be administered either orally or vaginally and is taken 2 to 3 times daily for a period of a few months.
Rates of Success
In patients who take bromocriptine, 90% of women continue ovulating while on the drug while 65% to 85% of these women become pregnant. This wide range in percentage is dependant on a wide variety of factors, including the woman's age and the quality of the man's sperm.
Clomiphene leads to an 80% ovulation success rate with 40% of these women being successful in becoming pregnant. Thirty to sixty percent of these pregnancies result in live births.
Gonadotropins leads to a 20 to 60% rate of success in conceiving, while the live birth rate is estimated to be 75 to 80%.
Side Effects
Clomiphene often results in stomach pain, mild swelling of the ovaries, vomiting and, in rare cases, ovarian cysts.
Gonadotropins can lead to such symptoms as weight gain and tenderness, while bromocriptine can lead to fatigue, headaches and diarrhea.
Women should be aware that taking fertility drugs is an emotionally exhausting process that requires frequent check ups and regular monitoring. Establishing a support system (including a doctor whom you and your partner trust and a friend or loved one in whom to confide) is crucial step you should take before beginning any fertility treatment plan.
Risks
Like IVF, fertility drugs increase the risk of multiple births.
Multiple births pose special risks because they increase the chance of miscarriage and preterm labor. Premature babies often have serious health problems, such as underdeveloped lungs.
Gonadotropins increase the risk of multiple births by 10 to 40%, while 10% of clomiphene users conceive multiple babies, usually twins.
Bromocriptine doesn't increase a woman's chance of giving birth to multiple babies.
To reduce the risk of multiple births, a woman must be closely monitored by her physician; adjusting the dosage of the prescribed drug is another option.
A recent study found that fertility drugs do not increase a woman's risk of developing ovarian cancer, putting an end to years of debate over the link between ovarian cancer and fertility drug use.
For the 7.1% of American married couples who have infertility problems, alternative fertility options, such as fertility drugs and assisted reproductive technologies (ART) can provide for them a way to achieve their dreams of becoming parents.
But these fertility treatments aren't cheap. What is the price of common alternative fertility treatments? And are they really worth it? Do all health insurance plans cover the cost of fertility treatment?
Fertility Drugs
Fertility drugs are usually the first step in alternative fertility treatment.
Clompihene is a common fertility drug given to women with hormonal imbalances and Polycystic Ovarian Syndrome (PCOS). Clomiphene costs a minimum of $50 for one cycle; this cost doesn't include medical visits, ultrasounds, or follow-up artificial insemination procedures, should they be required.
Clomiphene leads to an 80% ovulation success rate with 40% of these women successfully becoming pregnant. Thirty to sixty percent of these pregnancies result in live births.
Gonadotropins, which is sometimes used in conjunction with In Vitro Fertilization (IVF), costs approximately $2 000 to $5 000; this price includes tests, drugs and medical check-ups. Gonadotropins leads to a 20 to 60% rate of success in conceiving, while the live birth rate is estimated to be 75 to 80%.
Another common fertility drug, bromocriptine, requires $75 to $112 per cycle. In patients who take bromocriptine, 90% of women continue ovulating while on the drug while 65% to 85% of these women become pregnant.
If your insurance policy doesn't cover the cost of fertility drugs such as the ones above, you'll have to pay the cost up front.
Assisted Reproductive Technologies
Ten to fifteen percent of couples that see a fertility specialist require ART in order to become pregnant.
Intrauterine insemination (IUI, in which sperm is placed in the womb using artificial means) costs $345, a cost which includes the cost of semen analysis, sperm preparation; insemination.
IVF is a process in which eggs from the ovary and sperm are injected into the womb if they become fertilized; it has a 35% success rate of becoming pregnant, with a 28% success rate of delivering a baby.
A frozen embryo transfer (which saves any eggs not used in an IVF cycle) costs approximately $2545.
Gamete intrafallopian transfer (GIFT) is a process in which the eggs and sperm are mixed in the lab and then surgically implanted in the womb; GIFT has a 25 to 30% success rate of becoming pregnant, with a cost of between $8 000 to $15 000.
Zygote intrafallopian transfer (ZIFT) is a process similar to GIFT, except that doctors make sure the egg is fertilized before implanting it into the womb. ZIFT also has a success rate of 25 to 30% success rate of conceiving and also costs between $8 000 to $15 000.
Suggestions for Financial Aid: Health Insurance and Other Options
You should thoroughly research whether your health insurance policy covers fertility drugs or fertility treatment before committing to any plan. Also, be aware that fertility treatment costs vary from state to state.
Studies have found that the earlier couples visit reproductive specialists, the lower the overall cost of fertility treatment will be. This is because the appropriate tests are conducted to diagnose the cause of infertility. As a result, less time and money is wasted on fertility drugs that aren't effective, and you have a greater chance of becoming pregnant more quickly.
Also, waiting too long to seek fertility treatment isn't cost-effective. Fertility decreases with age, especially after the age of 35. If you wait until you're older, chances are you'll have to spend even more money on fertility treatments in order to become pregnant.
A study found that of 355 American employers, 41% offer health insurance policies that cover at least one type of infertility treatment, but many of these didn't pay for IVF.
Over 65% of American employees offer insurance policies that are exempt from state mandates that require health insurance companies to make available a policy covering fertility treatment.
Many fertility clinics have financial aid counselors, who can help you set up a loan. If your credit rating is strong, you can have access to low interest rates.
Many health insurance policies cover prescription medications that can sometimes balance the costs of fertility treatments.
Shared Risk is a popular program in which an individual pays for a certain number of IVF cycles at the start of the program (typically four cycles) and if you're not pregnant after the specified number of cycles, you don't have to pay.
Fertility treatment can create a lot of financial, emotional and physical stress. Many reproductive centers offer financial counseling, and can help you find an affordable, individual health insurance that's right for you. However, it's imperative to start budgeting before you start any fertility process in order to avoid disappointment and unnecessary stress.
Treating Female Infertility: Recombinant FSH (rFSH)
For couples experiencing difficulty getting pregnant, finding the proper infertility treatment can often become an overwhelming task. However, for women experiencing abnormal ovulation cycles, there may be hope in recombinant follicle stimulating hormone (rFSH). This fertility drug works by stimulating ovulation using synthetic female hormones, in effect improving a woman's overall fertility.
What is Recombinant FSH?
Follicle-stimulating hormone is a special hormone that is secreted by the pituitary gland; a small gland located in the brain. This hormone belongs to a group of hormones known as gonadotropins, which are responsible for stimulating the ovaries. In women, FSH's job is to stimulate the development of follicles inside your ovaries so that they can mature and release eggs for fertilization.
Recombinant FSH is a synthetic form of FSH that is produced using DNA technology. It is used to help induce ovulation in preparation for fertility treatments, like IUI and in vitro fertilization (IVF). It is most often recommended for women whose ovaries produce follicles but lack sufficient hormones to stimulate their development. This often comes as a result of a preexisting reproductive health condition, such as:
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anovulation
irregular menstruation
amenorrhea
PCOS (polycystic ovarian syndrome)
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thyroid problem
adrenal dysfunction
cancer of the breast, ovary, uterus, hypothalamus or pituitary gland
undiagnosed abnormal vaginal bleeding
ovarian cysts or enlargement not caused by PCOS
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ovarian enlargement manifested in abdominal or pelvic pain, tenderness or swelling
breast tenderness
fluid retention and swelling
headache
fatigue or dizziness
irritability
fever or chills
spotting or menstrual changes
dry skin, rash or hair loss
rapid pulse or heart rate
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an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives)
pain, warmth, redness, numbness, or tingling in an arm or leg (which may indicate a blood clot);
confusion, severe dizziness, severe headache; or
difficulty breathing
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Low levels of FSH
Abnormal levels of LH
POS
anovulation
unexplained infertility
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abdominal pain
bloating
swelling or redness at the injection site
risk of multiple pregnancies
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infrequent urination
digestion problems
pain, nausea, and vomiting
fever or chills
rapid weight gain or hair loss
risk of developing hyperstimulation syndrome
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constipation or diarrhea
dizziness and headaches
fatigue
nausea and vomiting
upset stomach or cramps
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shortness of breath
irregular pulse
rashes
involuntary movements
tingling of hands or feet
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polycystic ovary syndrome (PCOS)
luteal phase defects
unexplained infertility
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hormonal imbalance
oligospermia (low sperm count)
hypogonadism
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Heart complications
Ovarian Hyperstimulation Syndrome
Ovarian enlargement
Ovarian cysts
Adnominal pain
Flu-like symptoms
Pain and swelling at injection site
Body rashes
Multiple pregnancies
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blood clots (thrombosis)
dizziness
endometrial cancer
endometriosis
hair and/or nail thinning
headaches
indigestion
irregular menstruation
nausea
visual problems
voice changes
weight gain
risk of multiple births
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Endometriosis
Low levels of LH
Low levels of FSH
Ovary disorders like PCOS
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anovulation
irregular menstruation
polycystic ovary syndrome (PCOS)
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abdominal discomfort
headaches
mood changes
nausea
indigestion
sore breasts
tiredness
water retention
weight gain
risk of multiple births